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{"pathway":"Pentose phosphate pathway","pval":0.41379,"padj":0.87662,"DysPS":0.25011,"NDysPS":1.04954,"nMoreExtreme":23,"size":83,"leadingEdge":["PRPS1L1|TKT","ALDOB|TKTL1","ALDOC|FBP1","GPI|TKTL1","PFKL|TKT","PGM1|RPIA","ALDOC|TALDO1","ALDOA|ALDOB","GPI|PFKP","ALDOC|PFKP","PRPS1L1|TKTL1","FBP1|TALDO1","TKT|TKTL1","PRPS2|TKTL1","RPE|RPIA","FBP1|PFKM","PGD|RPIA","ALDOC|TKT","ALDOA|FBP1","GPI|PFKL","ALDOC|FBP2","PFKL|TALDO1","ALDOC|TKTL1","RPIA|TKT","ALDOB|PFKP","PGM1|TKT","FBP2|GPI","RPE|TKT","ALDOA|FBP2","ALDOA|TKT","TALDO1|TKTL1","ALDOA|PFKP","ALDOB|TALDO1","ALDOB|PFKM","FBP1|GPI","PFKL|TKTL1","FBP1|PFKP","GPI|TKT","PRPS1|TKTL1"]}
{"pathway":"Pentose and glucuronate interconversions","pval":0.3,"padj":0.79773,"DysPS":0.30893,"NDysPS":1.10395,"nMoreExtreme":17,"size":41,"leadingEdge":["UGT2B17|UGT2B4","AKR1A1|KL","UGT2B4|UGT2B7","KL|UGT2A1","UGDH|UGT2A1","UGT2A1|UGT2B7","UGT2A1|UGT2B4","GUSB|UGT2B7","UGT2A1|UGT2B11","KL|UGT2B17","UGT2B11|UGT2B4","GUSB|UGT2B11","GUSB|UGT2B15","UGDH|UGT2B15","UGT2A1|UGT2B17","UGT2B15|UGT2B4","AKR1A1|GUSB"]}
{"pathway":"Fructose and mannose metabolism","pval":0.92188,"padj":0.94521,"DysPS":0.1663,"NDysPS":0.7307,"nMoreExtreme":58,"size":95,"leadingEdge":["HK2|PFKP","MPI|PFKFB3","ALDOC|FBP1","MPI|PFKL","FBP2|MPI","HK2|PFKFB3","ALDOA|ALDOB","ALDOC|PFKP","HK3|MPI","HK2|PFKFB2","HK3|PFKP","FBP1|PFKM","HK2|PMM2","MPI|PFKP","PFKFB3|PFKL","ALDOB|TPI1","FBP1|PFKFB3","ALDOA|FBP1","MPI|PMM2","ALDOC|FBP2","FBP1|MPI","FBP2|PFKFB1","FBP2|PFKFB3","FBP1|PFKFB4","HK3|KHK","FBP2|HK2","ALDOB|PFKP","HK3|PFKFB2","KHK|SORD","PFKFB4|PFKL","ALDOA|FBP2","ALDOA|PFKP","PFKFB2|PFKL","ALDOC|TPI1","ALDOB|PFKM","HK3|SORD","FBP1|PFKP","PFKFB4|PFKM","PFKFB1|PFKM","PFKFB3|PFKM"]}
{"pathway":"Galactose metabolism","pval":0.02564,"padj":0.42188,"DysPS":-0.36588,"NDysPS":-1.48734,"nMoreExtreme":0,"size":48,"leadingEdge":["GAA|GLA","GALT|PGM1","AKR1B10|LCT","GLA|GLB1","AKR1B10|GLA","B4GALT2|GALT","GCK|PGM1","GALE|GALT","GLA|LCT","GALK1|GALT","AKR1B1|GLA","GLA|SI","AKR1B1|GLB1","GLA|MGAM","LALBA|LCT"]}
{"pathway":"Arginine biosynthesis","pval":0.175,"padj":0.74605,"DysPS":-0.3415,"NDysPS":-1.27356,"nMoreExtreme":6,"size":37,"leadingEdge":["ARG1|OTC","ARG1|NOS1","GLUD1|GOT1","ARG2|OTC","ACY1|ARG1","CPS1|GLS2","GLUD2|GPT","GLS2|GLUL"]}
{"pathway":"Alanine, aspartate and glutamate metabolism","pval":0.94118,"padj":0.95294,"DysPS":-0.17107,"NDysPS":-0.73606,"nMoreExtreme":31,"size":66,"leadingEdge":["ADSL|ASL","ASPA|CAD","ALDH4A1|GLS","CAD|GFPT2","GAD1|GLUD2","CAD|GLUL","CPS1|GLS2","GFPT2|GLS2","GLS2|GLUL","GAD2|GLS2"]}
{"pathway":"Glycine, serine and threonine metabolism","pval":0.39535,"padj":0.87662,"DysPS":-0.22558,"NDysPS":-1.04155,"nMoreExtreme":16,"size":84,"leadingEdge":["GATM|GLDC","AGXT|GCAT","AGXT|GATM","PSPH|SDS","AGXT|DAO","AGXT|GRHPR","ALAS2|GNMT","PSPH|SHMT1","ALAS2|SARDH","ALAS1|GCAT","GCAT|SARDH","GCAT|GNMT","PSPH|SRR","DLD|GLDC","GATM|SARDH","GCAT|GLDC","CBS|SHMT1","GLDC|SHMT1","ALAS2|SHMT2","AGXT|GLDC","GATM|GNMT","AGXT|PSPH","ALAS1|GNMT","DAO|SHMT2","AGXT|CBS","AGXT|SDS","GLDC|GNMT","ALAS2|DAO","DAO|GCAT","ALAS2|GLDC","AMT|DLD","ALAS2|GATM"]}
{"pathway":"Cysteine and methionine metabolism","pval":0.76471,"padj":0.91712,"DysPS":0.19724,"NDysPS":0.81044,"nMoreExtreme":51,"size":67,"leadingEdge":["AHCYL1|MTR","AHCYL1|DNMT1","AHCY|MTR","AMD1|SRM","GOT2|MDH2","AMD1|SMS","CBS|CTH","GCLC|GSS","AHCY|DNMT1","MAT2A|MTR","GOT1|LDHC","DNMT1|MAT2A","BCAT1|GCLM","DNMT1|MAT1A","LDHC|MPST"]}
{"pathway":"Lysine degradation","pval":0.875,"padj":0.93257,"DysPS":-0.2101,"NDysPS":-0.71361,"nMoreExtreme":34,"size":27,"leadingEdge":["PLOD3|PRDM2","GCDH|HADHA","DLD|GCDH","ALDH1B1|BBOX1","DLST|GCDH","ACAT2|EHHADH","DOT1L|PLOD3","PLOD3|SETDB1","ALDH2|BBOX1","ALDH9A1|BBOX1"]}
{"pathway":"Arginine and proline metabolism","pval":0.42105,"padj":0.87662,"DysPS":-0.24402,"NDysPS":-1.00953,"nMoreExtreme":15,"size":52,"leadingEdge":["P4HA1|PYCR1","ALDH4A1|PRODH2","ALDH7A1|MAOA","ARG1|NOS1","CKM|GAMT","ALDH7A1|MAOB"]}
{"pathway":"Phenylalanine metabolism","pval":0.0303,"padj":0.42188,"DysPS":-0.45797,"NDysPS":-1.75169,"nMoreExtreme":0,"size":43,"leadingEdge":["GOT1|HPD","ALDH3B1|AOC3","ALDH1A3|AOC3","AOC3|MAOB","ALDH3A1|AOC3","AOC2|MAOA","AOC2|MAOB","HPD|MIF","ALDH3A1|AOC2","MIF|TAT","HPD|TAT","GOT2|HPD","GOT1|PAH","AOC3|DDC","ALDH1A3|MAOB","AOC3|MAOA","ALDH3B2|MAOA","DDC|MAOB","ALDH3A1|MAOA","DDC|GOT1","GOT1|GOT2","ALDH3A1|MAOB"]}
{"pathway":"Tryptophan metabolism","pval":0.075,"padj":0.51923,"DysPS":-0.37931,"NDysPS":-1.41493,"nMoreExtreme":2,"size":39,"leadingEdge":["ASMT|CYP1A1","ALDH7A1|MAOA","CAT|HAAO","ALDH7A1|MAOB","GCDH|HADHA","DLD|GCDH","DLST|GCDH","ALDH9A1|MAOB","ACAT2|EHHADH","AANAT|ASMT","DDC|MAOB","ALDH1B1|MAOA","ALDH2|ASMT","KMO|KYNU","ALDH3A2|MAOA","EHHADH|GCDH","DDC|MAOA"]}
{"pathway":"beta-Alanine metabolism","pval":0.55263,"padj":0.87662,"DysPS":-0.21351,"NDysPS":-0.98711,"nMoreExtreme":20,"size":98,"leadingEdge":["ALDH2|GAD2","ALDH3B1|AOC3","ALDH1A3|AOC3","ALDH3A2|AOC3","ALDH9A1|AOC2","ALDH3A1|AOC3","ALDH1A3|ALDH2","ALDH9A1|GAD2","AOC3|SMOX","ALDH3A1|AOC2","ALDH3B2|GAD1","ALDH9A1|SMOX","ALDH3B1|ALDH7A1","ALDH3A2|AOC2","ALDH3A1|SMOX","ALDH1B1|ALDH3B1","ALDH1B1|ALDH3B2"]}
{"pathway":"Starch and sucrose metabolism","pval":0.89062,"padj":0.93689,"DysPS":0.16808,"NDysPS":0.71152,"nMoreExtreme":56,"size":75,"leadingEdge":["AMY2A|SI","GYG2|UGP2","MGAM|PYGL","AMY2A|PYGL","PGM1|UGP2","AMY2A|GAA","GPI|HK3","AMY2A|PYGB","AMY2A|PYGM","GBE1|GYS1","G6PC|PGM1","GCK|HK3","AGL|MGAM"]}
{"pathway":"N-Glycan biosynthesis","pval":0.52459,"padj":0.87662,"DysPS":0.27883,"NDysPS":0.96653,"nMoreExtreme":31,"size":35,"leadingEdge":["FUT8|MGAT3","DDOST|TUSC3","ALG3|DPM1","B4GALT2|FUT8","RPN1|TUSC3","DAD1|TUSC3","DOLPP1|TUSC3","MAN1A2|MGAT1","DPAGT1|DPM1"]}
{"pathway":"Amino sugar and nucleotide sugar metabolism","pval":0.325,"padj":0.79773,"DysPS":-0.26059,"NDysPS":-1.09706,"nMoreExtreme":12,"size":49,"leadingEdge":["MPI|PMM1","HK2|MPI","GCK|PGM1","GALE|GALT","GNPDA1|MPI","CHIT1|RENBP","HK3|PMM2","GCK|GPI","GNPDA1|GPI","GFPT1|GNPDA1","GALK1|GALT","GPI|MPI","GFPT2|HK2","HK2|PMM1","UGDH|UGP2","PMM1|PMM2","GPI|PGM1"]}
{"pathway":"Glycosaminoglycan degradation","pval":0.2381,"padj":0.79773,"DysPS":-0.35566,"NDysPS":-1.15619,"nMoreExtreme":9,"size":22,"leadingEdge":["GUSB|HYAL3","HYAL3|IDUA","GUSB|HYAL2","GUSB|HYAL1","GNS|HEXA","ARSB|IDUA","IDUA|SGSH","IDUA|SPAM1","ARSB|HYAL1"]}
{"pathway":"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis","pval":0.84615,"padj":0.93257,"DysPS":-0.22449,"NDysPS":-0.73931,"nMoreExtreme":32,"size":26,"leadingEdge":["PIGK|PIGO","PIGC|PIGL"]}
{"pathway":"Ether lipid metabolism","pval":0.63889,"padj":0.87662,"DysPS":-0.20583,"NDysPS":-0.90116,"nMoreExtreme":22,"size":64,"leadingEdge":["PAFAH2|PLA2G6","ENPP2|PLA2G10","PAFAH1B1|PLA2G2A","PAFAH1B1|PLA2G1B","PLA2G1B|PLD2","PLA2G10|PLD1","PAFAH2|PLA2G1B","PAFAH2|PLA2G5","ENPP2|PLA2G4A","PLA2G4C|PLD2","PAFAH1B2|PLA2G2A","GAL3ST1|UGT8","PLA2G1B|PLD1","PAFAH1B2|PLA2G4A","ENPP2|PLA2G1B","PAFAH1B2|PLA2G1B","PLA2G5|PLD2"]}
{"pathway":"Linoleic acid metabolism","pval":0.09524,"padj":0.55102,"DysPS":-0.28127,"NDysPS":-1.28581,"nMoreExtreme":3,"size":81,"leadingEdge":["CYP3A4|PLA2G6","CYP2E1|PLA2G4A","ALOX15|PLA2G1B","CYP2E1|PLA2G6","ALOX15|CYP1A2","CYP1A2|CYP2E1","CYP2C8|CYP2J2","CYP1A2|CYP2C8","CYP2J2|CYP3A4","CYP1A2|PLA2G10","CYP2C19|PLA2G5","CYP2J2|PLA2G5","CYP2J2|PLA2G4C","ALOX15|PLA2G4C","CYP2E1|PLA2G10","CYP3A4|PLA2G4C","CYP1A2|PLA2G4A","CYP2E1|CYP3A4","CYP2C19|PLA2G10","CYP2C8|PLA2G5","CYP2C8|CYP2E1","CYP3A4|PLA2G10","CYP2C8|PLA2G1B","CYP2J2|PLA2G1B","CYP2C19|PLA2G6","CYP2E1|PLA2G1B","CYP1A2|CYP2J2"]}
{"pathway":"Sphingolipid metabolism","pval":0.21622,"padj":0.79773,"DysPS":-0.30788,"NDysPS":-1.24072,"nMoreExtreme":7,"size":46,"leadingEdge":["SGPL1|SPHK2","SMPD2|UGCG","ASAH1|SMPD2","GLA|NEU3","GBA|SMPD2","ARSA|NEU3","ARSA|GALC","GALC|GLA","UGCG|UGT8","NEU3|UGT8","GAL3ST1|NEU1","GAL3ST1|UGT8","SMPD1|UGCG","GBA|SMPD1"]}
{"pathway":"Glycosphingolipid biosynthesis - lacto and neolacto series","pval":0.03125,"padj":0.42188,"DysPS":0.35325,"NDysPS":1.55213,"nMoreExtreme":1,"size":95,"leadingEdge":["FUT2|GCNT2","FUT1|FUT4","B3GNT3|FUT4","B3GALT5|B4GALT1","FUT3|FUT4","FUT4|FUT5","B3GALT2|FUT3","B4GALT1|FUT3","FUT6|FUT9","B4GALT3|FUT2","B4GALT4|FUT3","B3GALT2|B4GALT4","ABO|FUT2","B4GALT3|B4GALT4","B4GALT1|FUT5","B4GALT4|FUT5","FUT6|GCNT2","B3GNT3|B4GALT3","B3GNT3|FUT9","B4GALT3|GCNT2","B4GALT3|FUT4","B3GNT3|B4GALT4","B3GALT2|FUT1","B3GNT3|B4GALT1","B4GALT2|FUT2","B4GALT4|FUT9","B3GALT5|B4GALT4","B4GALT3|FUT5","B3GALT2|FUT2","FUT2|FUT6","B4GALT1|FUT1","B4GALT2|FUT9","FUT2|FUT3","FUT5|FUT7","B3GALT5|FUT3","B4GALT4|FUT4"]}
{"pathway":"Glyoxylate and dicarboxylate metabolism","pval":0.47619,"padj":0.87662,"DysPS":0.29634,"NDysPS":0.99719,"nMoreExtreme":29,"size":26,"leadingEdge":["ACAT1|CS","ACAT2|CS","ACO1|ACO2","GCSH|SHMT2","CS|MDH2","AGXT|SHMT2","AMT|SHMT1","AGXT|HAO1","GLDC|SHMT2","AGXT|SHMT1"]}
{"pathway":"Propanoate metabolism","pval":0.70769,"padj":0.87662,"DysPS":0.2155,"NDysPS":0.8532,"nMoreExtreme":45,"size":59,"leadingEdge":["SUCLA2|SUCLG2","ACACB|ACAT1","BCKDHB|LDHA","ECHS1|HADHA","ACADS|PCCA","ACACA|ACAT1","EHHADH|HIBCH","ACOX1|PCCA","ALDH6A1|PCCA","ACADS|ACOX3","ECHS1|EHHADH","BCKDHA|LDHC","ACOX1|ECHS1","ACOX3|HADHA","ECHS1|HIBCH","ACADS|EHHADH","ACACB|ACAT2","ACOX1|ACOX3","ACADS|ACOX1","DBT|PCCB","ACOX3|ALDH6A1","ACOX3|EHHADH","ACOX3|PCCB","ACOX1|ALDH6A1","BCKDHA|DBT","ACADS|ECHS1","ACAT1|ALDH6A1"]}
{"pathway":"Butanoate metabolism","pval":0.51613,"padj":0.87662,"DysPS":0.28414,"NDysPS":0.94978,"nMoreExtreme":31,"size":28,"leadingEdge":["ACAT1|HMGCS1","HMGCL|HMGCS2","ECHS1|HADHA","EHHADH|HMGCS2","ACAT1|ACAT2","ACAT1|HMGCS2","ECHS1|EHHADH","ACADS|EHHADH","ABAT|GAD2","ACAT1|HMGCL","HMGCS1|OXCT1","ABAT|ALDH5A1","ACADS|ECHS1","ACAT2|HMGCS1","ACADS|HADHA","ACAT2|HMGCS2","ACAT2|OXCT1","EHHADH|HADHA"]}
{"pathway":"One carbon pool by folate","pval":0.01587,"padj":0.42188,"DysPS":0.41824,"NDysPS":1.62277,"nMoreExtreme":0,"size":51,"leadingEdge":["MTHFR|TYMS","MTHFD1|MTR","ATIC|MTR","GART|MTR","ATIC|SHMT1","MTHFD2|SHMT1","AMT|MTHFR","SHMT1|SHMT2","DHFR|SHMT1","DHFR|MTR","MTHFD1|TYMS","ATIC|DHFR","DHFR|GART","ATIC|MTHFD2","AMT|SHMT1","GART|SHMT1","MTHFD1|SHMT1","MTHFR|MTR","MTHFD1|SHMT2","SHMT1|TYMS","AMT|SHMT2","AMT|TYMS","GART|SHMT2","MTHFD2|SHMT2","MTR|SHMT1","GART|MTHFS","DHFR|MTHFD1"]}
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{"pathway":"Porphyrin and chlorophyll metabolism","pval":0.58974,"padj":0.87662,"DysPS":-0.21931,"NDysPS":-0.91673,"nMoreExtreme":22,"size":50,"leadingEdge":["FXN|HMOX1","GUSB|UGT2B4","ALAD|ALAS2","COX10|HMOX1","BLVRA|HMOX2","BLVRB|UGT2B4","FECH|HMOX1","FXN|HMOX2","BLVRA|UGT2B7"]}
{"pathway":"Terpenoid backbone biosynthesis","pval":0.21667,"padj":0.79773,"DysPS":0.38164,"NDysPS":1.25611,"nMoreExtreme":12,"size":25,"leadingEdge":["FNTB|RCE1","FNTA|ZMPSTE24","ACAT1|HMGCS1","ICMT|ZMPSTE24","ACAT1|ACAT2","ACAT1|HMGCS2"]}
{"pathway":"Drug metabolism - other enzymes","pval":0.13793,"padj":0.66176,"DysPS":0.27766,"NDysPS":1.20155,"nMoreExtreme":7,"size":89,"leadingEdge":["DUT|TK1","CES1|NAT1","CYP2A6|DPYD","HPRT1|TPMT","CES1|UGT2B15","CES1|UGT2B17","HPRT1|IMPDH1","CES2|UGT2A1","GMPS|IMPDH1","NME1|RRM1","NME2|RRM1","CES1|NAT2","CDA|CES2","CYP2E1|GSTA2","CES1|UGT2B11","DUT|NME2","GMPS|TPMT","GUSB|UGT2B7","IMPDH1|ITPA","CES1|GUSB","HPRT1|IMPDH2","CYP2E1|MGST3"]}
{"pathway":"Platinum drug resistance","pval":0.09231,"padj":0.55102,"DysPS":0.31328,"NDysPS":1.31791,"nMoreExtreme":5,"size":73,"leadingEdge":["AKT1|BAD","AKT1|BIRC5","AKT1|BIRC3","BCL2L1|PMAIP1","BAK1|TP53","AKT1|BIRC2","BAD|BCL2L1","PDPK1|PIK3CA","FAS|TP53","AKT2|BIRC5","ATM|TP53","BAD|BCL2","AKT2|BAD","BID|CASP8","CASP8|FADD","BIRC2|CASP9","BAX|TP53","BAK1|BCL2","BBC3|BCL2L1","BBC3|TP53","ERBB2|PIK3CD"]}
{"pathway":"RNA transport","pval":0.14706,"padj":0.66176,"DysPS":-0.29265,"NDysPS":-1.2602,"nMoreExtreme":4,"size":67,"leadingEdge":["EIF2B4|EIF2S1","NXF1|NXT2","EIF4A1|EIF4G1","RANBP2|SUMO3","RNPS1|SAP18","ACIN1|SAP18","NUP214|NUP88","EIF4A2|EIF4G2","EIF4A1|EIF4G3","SUMO1|UBE2I","PNN|SAP18","EIF4A1|EIF4B","EIF4E2|EIF4G3","EIF4E|EIF4G2","PABPC1|PAIP1","EIF4A2|EIF4G3","RANBP2|RANGAP1","EIF2B5|EIF2S1","RAN|XPO1","NXF1|RAE1","UPF2|UPF3A","CYFIP1|FXR2","MAGOH|RBM8A","SUMO4|UBE2I","THOC1|THOC2","EIF4E2|EIF4G1","EIF2B5|EIF2S2","EEF1A2|RAN","RANBP2|UBE2I","NXF1|UPF3A","NCBP1|RAN"]}
{"pathway":"mRNA surveillance pathway","pval":0.7971,"padj":0.92236,"DysPS":0.21403,"NDysPS":0.79306,"nMoreExtreme":54,"size":43,"leadingEdge":["PPP2R5A|SMG1","GSPT1|UPF3A","CSTF3|SYMPK","MSI1|PABPC1","CPSF1|PPP1CB","PPP2R2A|SMG1","PPP1CA|PPP1CB","CPSF4|PPP1CC","CSTF1|CSTF3","PPP2R5B|SMG1","CPSF1|PPP1CA"]}
{"pathway":"Fanconi anemia pathway","pval":1,"padj":1,"DysPS":-0.15153,"NDysPS":-0.51961,"nMoreExtreme":38,"size":29,"leadingEdge":["ATR|FANCA","MLH1|PMS2","ATR|FANCG","BLM|TOP3B","FANCA|FANCL","RPA1|TOP3B","ATR|BRCA1","BLM|TOP3A","BRCA2|RAD51C","BLM|RPA2","FANCL|HES1","TOP3A|TOP3B"]}
{"pathway":"Viral protein interaction with cytokine and cytokine receptor","pval":0.61765,"padj":0.87662,"DysPS":-0.22091,"NDysPS":-0.95051,"nMoreExtreme":20,"size":66,"leadingEdge":["CCL13|CCR3","CCL27|CCR3","TNFRSF10B|TNFSF10","CCL5|CCR5","TNFRSF14|TNFSF14","CCL13|CCR2","CCL27|CCR2","CCL7|CCR3","IL6|IL6R","IL2|IL2RG","CXCL10|CXCR3","IL2RA|IL2RB","CCL14|CCR1","CCL8|CCR1","CCL17|CCR4"]}
{"pathway":"FoxO signaling pathway","pval":0.47692,"padj":0.87662,"DysPS":0.22547,"NDysPS":0.99777,"nMoreExtreme":30,"size":96,"leadingEdge":["MAP2K1|MAPK1","IL6|STAT3","PDPK1|PIK3CA","BRAF|NRAS","EGF|EGFR","IRS2|PIK3CA","MAP2K2|RAF1","IKBKB|PTEN","GRM1|HOMER1","HOMER3|PIK3R1","AKT1|CHUK","AKT3|IKBKB","CHUK|PDPK1","HRAS|RAF1","IKBKB|PDPK1","TGFB2|TGFBR1","IGF1R|IRS4","HOMER1|PIK3CD","IRS4|PIK3R3","PRKAA2|STK11","HOMER3|PIK3CA","MAP2K2|MAPK3","IGF1|IGF1R","HOMER2|PIK3R3","IRS4|PIK3R1","HOMER1|PIK3R2","AKT2|CHUK","PRKAB1|STK11","BRAF|MAP2K1","INSR|IRS1"]}
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{"pathway":"Mitophagy - animal","pval":0.525,"padj":0.87662,"DysPS":-0.27019,"NDysPS":-1.00761,"nMoreExtreme":20,"size":37,"leadingEdge":["JUN|MAPK9","BNIP3L|GABARAPL2","BECN1|PINK1","JUN|MAPK8","BNIP3|HIF1A","MFN2|PINK1","PINK1|TOMM7","PINK1|UBB","BNIP3L|GABARAPL1","BNIP3|GABARAPL2","GABARAPL2|OPTN","MITF|TFE3","HIF1A|RRAS2","HIF1A|RRAS"]}
{"pathway":"Protein processing in endoplasmic reticulum","pval":0.28571,"padj":0.79773,"DysPS":-0.34433,"NDysPS":-1.14106,"nMoreExtreme":11,"size":23,"leadingEdge":["ATF4|EIF2S1","BCL2|DDIT3","MAP2K7|MAPK8","BAX|CAPN1","ATF4|DDIT3","MAP2K7|MAPK10"]}
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{"pathway":"Notch signaling pathway","pval":0.70149,"padj":0.87662,"DysPS":0.20806,"NDysPS":0.82976,"nMoreExtreme":46,"size":56,"leadingEdge":["HDAC1|NCOR2","NOTCH3|RFNG","MFNG|NOTCH4","EP300|MAML1","DTX2|NOTCH3","JAG1|NOTCH2","NCSTN|PSEN1","NOTCH2|RFNG","DTX2|NOTCH2","NCSTN|NOTCH3","DVL3|NOTCH3","JAG2|NOTCH4","DVL1|NOTCH4","ADAM17|NOTCH2","CTBP2|HDAC1","DTX4|NOTCH3","DVL1|NOTCH2","NOTCH4|NUMB"]}
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{"pathway":"Cell adhesion molecules (CAMs)","pval":0.04762,"padj":0.51923,"DysPS":0.36393,"NDysPS":1.43063,"nMoreExtreme":2,"size":60,"leadingEdge":["GLG1|SELE","CD8A|HLA-B","CD8A|HLA-C","CD4|HLA-DOB","ITGA9|ITGB1","CD8A|HLA-F","CD28|CD80","ITGA9|VCAM1","CD4|HLA-DMB","CD8A|HLA-A","NLGN4Y|NRXN3","CD8A|HLA-G","NLGN1|NRXN3","CD226|PVR","CD34|SELL","ITGAM|JAM3"]}
{"pathway":"Complement and coagulation cascades","pval":0.31579,"padj":0.79773,"DysPS":-0.25447,"NDysPS":-1.12762,"nMoreExtreme":11,"size":76,"leadingEdge":["F2|F2R","MASP1|MASP2","F11|F12","F2|FGB","F2|F2RL3","C4B|MASP1","C4A|MASP1","PROC|THBD","MASP2|SERPING1","F2|FGG","CPB2|F2","F2|SERPINC1","C1QB|SERPING1","F8|PROC","F13B|F2","F10|F9","F2|F5","F10|TFPI","MBL2|SERPING1","C1QB|C4B","C1QB|C4A","F12|PLG","F2|FGA","C1R|C4B","C1R|C4A","C2|MASP1","C1QB|C2","C1R|C2","C1S|C4B","C1S|C4A"]}
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{"pathway":"Circadian rhythm","pval":0.54412,"padj":0.87662,"DysPS":0.22929,"NDysPS":0.94453,"nMoreExtreme":36,"size":66,"leadingEdge":["CRY2|PRKAB1","CLOCK|NR1D1","CSNK1D|NPAS2","ARNTL|PER1","ARNTL|CRY2","CSNK1D|PER1","CRY1|PRKAA1","CRY1|CRY2","ARNTL|NPAS2","CLOCK|PER1","CSNK1E|PER1","CRY1|PRKAB2","CRY2|PRKAA2","CSNK1E|PER2","NPAS2|NR1D1","FBXW11|PER1","CSNK1D|CSNK1E","ARNTL|CSNK1E","CRY1|PRKAA2","CRY2|CSNK1D","CRY2|PRKAA1","CREB1|PER1","CLOCK|RORB","NPAS2|RORB","CRY2|PER2"]}
{"pathway":"Synaptic vesicle cycle","pval":0.06122,"padj":0.51923,"DysPS":-0.46666,"NDysPS":-1.56114,"nMoreExtreme":2,"size":20,"leadingEdge":["AP2A2|CLTA","SNAP25|STX1A","AP2A2|CLTB","AP2M1|CLTA","STX1A|VAMP2","AP2A2|CLTCL1","AP2B1|CLTA","AP2M1|CLTC","STX1A|STXBP1","AP2A2|CLTC","AP2M1|CLTB"]}
{"pathway":"Phototransduction","pval":0.87302,"padj":0.93257,"DysPS":0.20646,"NDysPS":0.73,"nMoreExtreme":54,"size":38,"leadingEdge":["RHO|SAG","CALM3|CNGA1","CALM1|CNGA1","GNB1|RGS9","GNAT2|RHO","GNAT2|PDE6B","GUCA1A|GUCY2D","GUCA1A|GUCY2F","GNGT1|RGS9","GNB1|PDE6G"]}
{"pathway":"Ovarian steroidogenesis","pval":0.78125,"padj":0.91712,"DysPS":0.18753,"NDysPS":0.79468,"nMoreExtreme":49,"size":76,"leadingEdge":["ADCY2|PLA2G4C","ADCY2|PRKACG","ADCY3|GNAS","ADCY2|PRKACB","CYP19A1|PRKACB","HSD3B2|PRKACB","PRKACA|STAR","AKR1C3|PRKACA","ADCY9|PRKACB","ADCY3|PRKACA","IGF1|IGF1R","ADCY7|PRKACA","ADCY3|PRKACG","GNAS|PLA2G4A","ADCY1|PRKACB","CYP17A1|PRKACB","ADCY6|PLA2G4A","ADCY6|PRKACB","ADCY7|PRKACG","AKR1C3|PRKACG","ADCY8|PRKACB"]}
{"pathway":"Renin secretion","pval":0.22059,"padj":0.79773,"DysPS":0.28672,"NDysPS":1.18359,"nMoreExtreme":14,"size":68,"leadingEdge":["ITPR2|PLCB1","CREB1|PRKACB","KCNMA1|PRKACB","ADORA1|GNAI2","CALM2|PPP3R1","KCNMA1|PRKACA","GNAS|PTGER4","ADCY6|GNAI3","ADCY6|GNAI2","EDNRA|KCNJ2","ITPR1|PLCB4","EDN3|EDNRA"]}
{"pathway":"Type II diabetes mellitus","pval":0.14634,"padj":0.66176,"DysPS":-0.25499,"NDysPS":-1.19613,"nMoreExtreme":5,"size":94,"leadingEdge":["INSR|SOCS3","INSR|MAPK1","IRS1|SOCS2","INSR|IRS2","IRS4|MAPK9","INSR|IRS4","IRS2|PIK3CB","INSR|SOCS1","PIK3R3|SLC2A4","IRS4|MAPK8","HK2|PKLR","PIK3R2|PRKCZ","IRS2|PIK3R2","PIK3R1|SLC2A4","IRS2|PIK3CD","IRS4|PRKCD","IRS2|PRKCD","ABCC8|CACNA1B","GCK|PKLR","ABCC8|CACNA1D","IRS2|PIK3R1"]}
{"pathway":"Aldosterone-regulated sodium reabsorption","pval":0.77778,"padj":0.91712,"DysPS":0.23345,"NDysPS":0.7899,"nMoreExtreme":48,"size":29,"leadingEdge":["PDPK1|PIK3CA","ATP1A3|NR3C2","ATP1A1|NR3C2","NEDD4L|SFN","NEDD4L|SCNN1A","FXYD2|NR3C2","NR3C2|SCNN1A","NEDD4L|SCNN1B","INSR|IRS1"]}
{"pathway":"Endocrine and other factor-regulated calcium reabsorption","pval":0.34211,"padj":0.81502,"DysPS":-0.27466,"NDysPS":-1.14088,"nMoreExtreme":12,"size":54,"leadingEdge":["ATP1A1|SLC8A1","ATP1B2|SLC8A2","PLCB4|PRKCG","BDKRB2|KLK2","ATP1A2|SLC8A1","ATP1A1|SLC8A2","ATP2B3|ESR1","ADCY6|PRKACG","ATP1B2|KL","PLCB1|PRKCA","PLCB3|PRKCA","ATP1B3|SLC8A1","ATP1A3|SLC8A2","ATP1A3|KL","ATP1A3|SLC8A1","GNAQ|PLCB1","ATP2B4|ESR1","ATP1B2|SLC8A1","ADCY9|PRKACG","PLCB2|PRKCG"]}
{"pathway":"Vasopressin-regulated water reabsorption","pval":0.66154,"padj":0.87662,"DysPS":0.24874,"NDysPS":0.92158,"nMoreExtreme":42,"size":46,"leadingEdge":["CREB1|PRKACB","ADCY3|GNAS","ARHGDIB|PRKACG","CREB3L2|PRKACB","ADCY9|PRKACB","CREB3|PRKACG","CREB3|PRKACB","ADCY3|PRKACA","ADCY3|PRKACG","AQP2|PRKACG","CREB3|PRKACA","ADCY6|PRKACB","CREB5|PRKACB"]}
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{"pathway":"Bile secretion","pval":0.65,"padj":0.87662,"DysPS":-0.23207,"NDysPS":-0.87302,"nMoreExtreme":25,"size":40,"leadingEdge":["ADCY1|PRKACG","ADCY1|PRKACA","CFTR|PRKACB","NR0B2|NR1H4","ADCY8|PRKACA","ADCY6|PRKACG","ABCB11|NR1H4","ABCB4|NR1H4","NR1H4|RXRA","CYP7A1|NR0B2","NR0B2|SLCO1B1","CFTR|PRKACA","GNAS|SCTR"]}
{"pathway":"Alzheimer disease","pval":0.71429,"padj":0.87662,"DysPS":-0.2125,"NDysPS":-0.88141,"nMoreExtreme":24,"size":56,"leadingEdge":["ITPR1|PLCB3","CALM1|PPP3CB","ITPR2|PLCB4","CALM2|PPP3CB","APOE|LRP1","CALM3|PPP3CC","LPL|LRP1","CALM2|PPP3CC","BAD|PPP3CC","APOE|LPL","ITPR3|PLCB4","CALM1|PPP3CC"]}
{"pathway":"Amyotrophic lateral sclerosis (ALS)","pval":0.45238,"padj":0.87662,"DysPS":-0.26366,"NDysPS":-1.032,"nMoreExtreme":18,"size":41,"leadingEdge":["BAD|CYCS","MAP2K3|MAPK11","MAPK13|NEFL","NEFL|SOD1","MAP2K3|MAPK12","BCL2|CYCS","MAPK13|NEFH","DAXX|TNFRSF1A","PPP3CA|SOD1","CASP3|CASP9","MAPK14|NEFH"]}
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{"pathway":"Bacterial invasion of epithelial cells","pval":0.06452,"padj":0.51923,"DysPS":0.33101,"NDysPS":1.39342,"nMoreExtreme":3,"size":77,"leadingEdge":["ARPC3|WASL","ACTG1|ARPC5L","ARPC1B|WASF1","CDC42|PIK3CA","RAC1|WASF2","GAB1|PIK3CA","CTNNA2|CTNNB1","ARPC1A|WASF1","ACTG1|ARPC1A","RAC1|WASF1","ARPC5L|WASL","CDC42|PIK3CB","ACTG1|VCL","ACTG1|RHOA","ILK|ITGB1","ARPC4|WASF2","CDC42|PIK3CD","ACTG1|ARPC2","CTNNA1|CTNNB1","CTTN|DNM2","CDC42|PIK3R2","CDC42|PIK3R1","CDC42|WASL","ACTG1|ARPC4","FN1|ITGA5","CDC42|PIK3R3","ARPC1A|WASL","CTTN|DNM3","PTK2|SRC","FN1|ITGB1","HCLS1|SRC","ACTB|ARPC5L","ARPC5L|WASF2","ARPC3|WASF2"]}
{"pathway":"Vibrio cholerae infection","pval":0.57143,"padj":0.87662,"DysPS":0.27456,"NDysPS":0.92388,"nMoreExtreme":35,"size":26,"leadingEdge":["ADCY3|GNAS","ADCY9|PRKACB","PLCG1|PRKCA","ADCY3|PRKACA","KCNQ1|SLC12A2","ADCY3|PRKACG","ACTG1|PRKCA","ACTB|PRKCA","ADCY3|KCNQ1"]}
{"pathway":"Epithelial cell signaling in Helicobacter pylori infection","pval":0.67647,"padj":0.87662,"DysPS":-0.2346,"NDysPS":-0.89991,"nMoreExtreme":22,"size":44,"leadingEdge":["JUN|MAPK9","CHUK|NFKBIA","MAP2K4|MAPK10","MAP3K14|PAK1","JUN|MAPK8"]}
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{"pathway":"Endometrial cancer","pval":0.32308,"padj":0.79773,"DysPS":0.25823,"NDysPS":1.08633,"nMoreExtreme":20,"size":73,"leadingEdge":["AKT1|BAD","MAP2K1|MAPK1","AXIN1|GSK3B","BAK1|TP53","PDPK1|PIK3CA","BRAF|NRAS","EGFR|PIK3R3","EGF|EGFR","MAP2K2|RAF1","AKT2|BAD","AXIN1|CTNNB1","HRAS|RAF1","ILK|PIK3R1","ILK|PIK3R3","EGFR|PIK3R1","AKT3|ILK","MAP2K2|MAPK3","BAX|TP53"]}
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{"pathway":"Bladder cancer","pval":0.57143,"padj":0.87662,"DysPS":0.28018,"NDysPS":0.99067,"nMoreExtreme":35,"size":38,"leadingEdge":["CDK4|CDKN2A","MAP2K1|MAPK1","BRAF|NRAS","EGF|EGFR","MAP2K2|RAF1","HRAS|RASSF1","HRAS|RAF1","MAP2K2|MAPK3","DAPK1|MAPK1","BRAF|MAP2K1","EGF|ERBB2","BRAF|HRAS","DAPK2|MAPK3","MAP2K1|MAPK3"]}
{"pathway":"Inflammatory bowel disease (IBD)","pval":0.41538,"padj":0.87662,"DysPS":0.26416,"NDysPS":1.04981,"nMoreExtreme":26,"size":58,"leadingEdge":["IL12RB2|IL18R1","IL6|STAT3","IL2RG|STAT6","IL18RAP|RELA","RELA|TLR5","IL12A|IL12RB2","IL12A|NFKB1","IFNG|JUN","IL12B|RELA","IL4R|STAT6","SMAD2|TGFB3","SMAD2|TGFB2","IFNG|IFNGR2","IL4|NFATC1","IL12A|RELA","IL18|IL18RAP","SMAD3|TGFB2"]}
{"pathway":"Graft-versus-host disease","pval":0.02564,"padj":0.42188,"DysPS":-0.54081,"NDysPS":-2.01206,"nMoreExtreme":0,"size":38,"leadingEdge":["CD28|CD86","HLA-E|KLRC1","HLA-G|KLRC1","HLA-C|KLRC1","HLA-B|KLRC1","HLA-F|KLRC1","HLA-E|KIR3DL2","HLA-C|KIR3DL1","HLA-C|KIR2DL3","HLA-C|KIR2DL1","HLA-B|KIR3DL1","HLA-B|KIR2DL3","HLA-B|KIR2DL1","HLA-G|KIR3DL2","HLA-C|KIR3DL2","HLA-B|KIR3DL2","HLA-G|KIR3DL1","HLA-G|KIR2DL3","HLA-G|KIR2DL1","HLA-F|KIR3DL2","HLA-A|KLRC1","HLA-E|KIR3DL1","HLA-E|KIR2DL3","HLA-E|KIR2DL1","HLA-F|KIR3DL1","HLA-F|KIR2DL3","HLA-F|KIR2DL1"]}
{"pathway":"Hypertrophic cardiomyopathy (HCM)","pval":0.85,"padj":0.93257,"DysPS":-0.21827,"NDysPS":-0.75684,"nMoreExtreme":33,"size":31,"leadingEdge":["TNNT2|TPM4","ACTG1|ITGB6","MYH6|MYL2"]}